N 5 (190) 2024. P. 35–39

INVESTIGATION OF IMMUNOLOGICAL INDICATORS IN THE ORAL FLUID OF MILITARY PERSONNEL WITH CHRONIC GENERALISED PERIODONTITIS WITH CONSIDERATION OF THEIR PSYCHO-EMOTIONAL STATE

Yu. L. Bandrivsky, V. O. Bilan

Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine

DOI 10.32782/2226-2008-2024-5-5

Diseases of periodontal tissues can lead to the appearance and development of complications in internal organs and systems that affect the general condition of the body and, most importantly, reduce the fighting and working capacity of military personnel.

The aim of the study – to investigate the content of immunological parameters in the oral fluid of the military personnel of the Armed Forces of Ukraine with chronic generalised periodontitis of the initial – stage II, taking into account their psycho-emotional state.

Materials and methods. The levels of certain cytokines (IL-2, IL-4 and TNF-α) and C-reactive protein (CRP) in oral fluid were measured in 94 patients with chronic generalised periodontitis (CGP) of the initial – stage II. The latex agglutination method was used to determine C-reactive protein (CRP) in oral fluid. The levels of IL-2, IL-4 and TNF-α in oral fluid were determined by enzyme-linked immunosorbent assay using a “Star Fax 303 Plus” device.

Results. As a result of laboratory studies in military personnel with initial – stage II CGP, an increase in the content of proinflammatory cytokines TNF-α – by 30.90% and IL-2 – by 57.89%, p<0.01, against the background of a decrease in the content of anti-inflammatory cytokine IL-4 – by 19.27%, p<0.05, compared with the data in the control group with initial – stage II CGP. There was a 62.10% increase in the level of CRP in the oral fluid in the control group compared to the data of civilians, p<0.01.

Conclusions. Thus, in the military personnel of the Ukrainian Armed Forces of the main group with the initial – stage II chronic generalised periodontitis, there was a significant increase in the level of C-reactive protein, proinflammatory cytokines TNF-α and IL-2 in the oral fluid against the background of a decrease in the content of proinflammatory cytokine IL-4, compared with the results of studies in civilians with the initial – stage II chronic generalised periodontitis of the control group.

Key words: generalised periodontitis, military personnel, oral fluid, cytokines, C-reactive protein.

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