N 3 (188) 2024. P. 14–18

CORRECTIVE EFFICACY OF NIACIN-OXY-ETHYLIDENE-DIPHOSPHONATE GERMANATE (MIGU-4) ON THE MODEL OF STREPTOZOTOCIN-INDUCED DIABETES

V. Y. Kresyun, N. J. Al-Nadawi

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2024-3-2

Background. Using organic germanium compounds is promising for developing pharmacological agents to prevent diabetes mellitus complications.

The study aimed to investigate the effectiveness of niacin-oxyethylene diphosphonate germanate (MIGU-4) on hyperglycemia, insulin level, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) activities, content of proteins, bilirubin, cholesterol, triglycerides, low and high-density lipoproteins (LDL and HDL, respectively) in the blood serum of rats with STZ-induced diabetes. A separate task was to compare the effectiveness of MIGU-4 with the use of vitamin E.

Materials and methods. Diabetes was induced in male Wistar rats by intraperitoneal administration of streptozotocin (65.0 mg/kg).

MIGU-4 was administered intraperitoneally at 25.0 mg/kg for four weeks.

Results. MIGU-4 caused a decrease in glucose levels by 50.9% and increased insulin content by 25.1% (p < 0.05) in diabetic rats. Besides, MIGU-4 restored albumin content (p < 0.05), reduced total bilirubin by 42.2%, cholesterol – by 30.6%, triglycerides – by 35.4%, LDL – by 58.6% and increased HDL by 48.4% (p < 0.05). The use of MIGU-4 reduced the activity of AST and ALT by 70,1% and 42.3% (p < 0.05). The activity of ALP and LDH was also reduced by 76.6% and 53.3% (p < 0.05). With vitamin E (100.0 mg/kg), AST and ALT activity decreased by 64.0% and 36.4% (p < 0.05) and remained higher than in control by 33.3% and 37.0%, respectively (p < 0.05). The activity of ALP and LDH decreased by 79.7% and 52.1% (p < 0.05).

Conclusions. MIGU-4 restores lipid metabolism, corrects serum liver function indices, and positively affects blood glucose and protein levels in streptozotocin-induced diabetes. Its effects (25.0 mg/kg) were comparable with those caused by vitamin E (100.0 mg/kg).

Key words: streptozotocin, diabetes mellitus, niacin-oxy-ethylidene-diphosphonate germinate, lipids, aminotransferases, vitamin E.

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