N 2 (187) 2024. P. 30–34

METABOLIC STATE OF BONE TISSUE IN PATIENTS WITH PERIODONTAL TISSUE DISEASES

V. М. Luchynskyi, T. І. Balaban, М. А. Luchynskyi, Yu. І. Luchynska, О. О. Stakhanska, Yu. K. Zmarko

Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine

DOI 10.32782/2226-2008-2024-2-5

Introduction. Pathological processes in the bone component of the periodontium associated with the systemic loss of mineral density of bone tissue contribute to the destruction of alveolar septa, premature tooth loss, and disruption of the dento-alveolar apparatus.

Research goal is to study the bone tissue metabolism in patients with periodontal tissue diseases and low skeletal mineral density.

Research methods. Examination of 242 people aged 18–60: 116 (47,93 %) – men and 126 (52,07%) – female. Females, in turn, were divided into 2 groups: 1st group – 61 women (48,41%) in reproductive period aged from 18 to 49 years; 2nd group – 65 women (51,59%) aged from 50 to 60 in the postmenopausal period. The content of osteocalcin, vitamin D3, and C-terminal telopeptide in the blood and deoxypyridinoline in the urine was assessed in the metabolism of bone tissue.

Research results and discussion. It was established that upon “normal” and “osteopenic” bone mineral density, the blood values of osteocalcin, vitamin D3, C-terminal telopeptide of human collagen type I did not differ statistically in men and women with generalized periodontitis, р>0.05. At the same time, in all states of bone mineral density, the level of deoxypyridinoline in women’s urine was, on average, 50.28% higher than that of men, р<0.05. With the increase in the intensification of dystrophic and inflammatory processes in the periodontal tissues, there was a tendency for the deterioration of the values of the parameters analyzed in the blood and urine of the examined patients, which were especially pronounced in women with generalized periodontitis in the postmenopausal period.

Conclusions. Based on the research carried out on male and female patients suffering from generalized periodontitis, certain aspects of the changes in bone metabolism markers were identified. These changes were found to be dependent on factors such as gender, bone tissue mineral density, and the severity of the generalized periodontitis.

Key words: periodontium, bone tissue, bone metabolism, osteocalcin, vitamin D3.

BIBLIOGRAPHY

  1. Alayash Z, Baumeister S, Reckelkamm S et al. Association between total body bone mineral density and periodontitis: A Mendelian randomization study. Journal of periodontology. 2023; 94(6): 777–784. doi: 10.1002/JPER.22-0249.
  2. Albeshri S, Alblaihess A, Niazy AA, Ramalingam S, Sundar C, Alghamdi HS. Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature. J Contemp Dent Pract. 2018; 19(5): 605–618. PMID: 29807974.
  3. Andreichyn MA, Chopiak VV, Hospodarskyi IYa. Klinichna imunolohiia ta alerholohiia: Pidruchnyk. Ternopil: Ukrmedknyha, 2005. 372 s. (in Ukrainian).
  4. Belluci MM, de Molon RS, Rossa CJr et al. Severe magnesium deficiency compromises systemic bone mineral density and aggravates inflammatory bone resorption. J Nutr Biochem. 2020; 77: 108301. doi: 10.1016/j.jnutbio.2019.108301. PMID: 31825817.
  5. Blufstein A, Behm C, Kubin B et al. Transcriptional activity of vitamin D receptor in human periodontal ligament cells is diminished under inflammatory conditions. Journal of periodontology. 2021; 92(1): 137–148. https://doi. org/10.1002%2FJPER.19-0541.
  6. Borysenko AV, Volovik IV. State of stomatological status in young adults depending on the presence of periodontal diseases. Suchasna stomatolohiia. 2016; 1: 28–34. (in Ukrainian). Available from: http://nbuv.gov.ua/UJRN/ss_2016_1_8.
  7. Cecilia Halling Linder, Barbro Ek-Rylander, Michael Krumpel et al. Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization. Calcif Tissue Int. 2017; 101(1): 92–101. doi: 10.1007/ s00223-017-0259-2.
  8. Hodovana О. І. Modern principles of etiology and pathogenesis of generalized dystrophic-inflam-matory periodontal diseases with concomitant systemic osteopenia. Visnyk problem biolohii i medytsyny. 2017; 1(137): 35–41 (in Ukrainian). Available from: http://repository.pdmu.edu.ua/bitstream/123456789/11803/1/Hodovana_Modern_principles_of_etiology.pdf.
  9. Gao J, Shui W, Ren L. Clinical Significance of Inflammatory Factors, Osteocalcin, and Matrix Metalloproteinase-8 in Gingival Crevicular Fluid in Drug Treatment of Severe Periodontitis. Evidence-based complementary and alternative medicine: Evid Based Complement Alternat Med. 2022; 8825540. doi: 10.1155/2022/8825540.
  10. Kohli N, Ho S, Brown S, Sawadkar P, Sharma V, Snow M, García-Gareta E. Bone remodelling in vitro: Where are we headed?: A review on the current understanding of physiological bone remodelling and inflammation and the strategies for testing biomaterials in vitro. 2018; 110: 38–46 doi: 10.1016/j.bone.2018.01.015.
  11. Kolenko UG., Volovyk IA., Myalkivsky KO. The influence of periodont tissue diseases on the quality of life of patients. Suchasna stomatolohiia. 2021; 2:36–42. (in Ukrainian). doi: 10.33295/1992-576X-2021-2-36.
  12. Hosseini S, Naderi-Manesh H, Vali H, Eslaminejad M, Sayahpour F, Sheibani S, Faghihi S. Contribution of osteocalcin-mimetic peptide enhances osteogenic activity and extracellular matrix mineralization of human osteoblast-like cells. Colloids Surf B Biointerfaces. 2019; 173: 662–671. doi: 10.1016/j.colsurfb.2018.10.035.
  13. Vadzyuk S, Boliuk Y, Luchynskyi M, Papinko I, Vadzyuk N. Prediction of the development of periodontal disease. Proceeding of the Shevchenko Scientific Society. Medical Sciences. 2021; 65(2): 107–117. (in Ukrainian). doi: https://doi.org/10.25040/ ntsh2021.02.10.
  14. Bandrivsky Y, Bandrivska O, Shkrebnyuk R, DyrykV. Prevalence of the generalized periodontitis in patients with different groups blood in depending on age and periodontal biotype. Wiadomości Lekarski. 2020; 1: 119–122. (in Ukrainian). doi: 10.36740/WLek202001123.
  15. Zhu L, Zhou C, Chen S et al. Osteoporosis and Alveolar Bone Health in Periodontitis Niche: A Predisposing Factors-Centered Review. Cells. 2022; 26; 11(21): 3380. doi: 10.3390/cells11213380. PMID: 36359775; PMCID: PMC9657655.
View article PDF