N 2 (187) 2024. P. 9–13

THE INFLUENCE OF THIOCETAM ON THE PARAMETERS OF PRO-OXIDANT AND ANTIOXIDANT SYSTEMS IN THE ADRENAL GLANDS UNDER EXPERIMENTAL PERIODONTITIS AND IMMOBILIZATION STRESS

M. S. Regeda, P. V. Olekshij, M. M. Regeda-Furdychko, S. M. Regeda,
M. A. Kolishetska

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Private higher education institution “Lviv medical university”, Lviv, Ukraine

DOI 10.32782/2226-2008-2024-2-1

The aim of the study is to find out the peculiarities of changes in lipids peroxidation and antioxidant system in the adrenal glands of animals under experimental parodontitis (EP) and immobilization stress (IS) and evaluate the effectiveness of the use of thiocetam.

The study was conducted on guinea pigs (males) with subsequent modeling of EP and IS and determination of the content of malonic dialdehyde, diene conjugates, superoxide dismutase, catalase and glutathione peroxidase in adrenal tissues before and after the use of thiocetam. An increase in lipoperoxidation processes was established against the background of antioxidant system suppression at all stages of EP and IS development, which indicated the presence of oxidant stress. The use of thiocetam led to an antioxidant effect under EP and IS conditions.

Conclusions. The development of oxidative stress in EP and IS has been established, which increases the course of periodontitis and stress, and the antioxidant effect of thiocetam has been proven.

Key words: periodontitis, stress, free radical oxidation, antioxidant protection, thiocetam.

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