N 4 (185) 2023. P. 94–98

IDENTIFICATION OF AMMONIUM HEXAFLUOROSILICATES USING CHEMICAL METHODS OF ANALYSIS

I. O. Shyshkin, O. V. Nikitin, V. O. Gelmboldt

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2023-4-18

Research goal. The aim of the work is to investigate the possibilities of chemical analysis methods for the identification of potential anti-caries agents – 3-hydroxymethyl-, 4-hydroxymethylpyridinium, 2-carboxymethylpyridinium and octenidinium hexafluorosilicates (I-IV, respectively).

Materials and methods. Compounds I-IV were synthesized earlier. It involved general alkaloid precipitation reagents, benzidine, 2,4-dinitrochlorobenzene, tropeolin 00, 000, iron (III) chloride, nickel (II) chloride, cobalt (II) nitrate – commercial preparations.

Results and discussion. The analysis procedures included the identification of the pyridine ring, hydroxymethyl and carboxyl groups, hexafluorosilicate anion in I-IV. 1% aqueous and methanolic solutions of I-IV were used. It was established that the reaction of the opening of the pyridine ring can be used for the identification of I-IV, followed by the confirmation of the formation of the derivative glutaconaldehyde and the reaction with general alkaloid precipitation reagents. Identification of the SiF 2– anion was carried out following standard reactions on the fluoride ion, taking into account its hydrolysis in dilute aqueous solutions with the formation of fluoride ions. Some characteristic reactions of identification of salts were revealed, in particular reactions of the formation of ionic associates with azo dyes tropeolins, which are extracted with chloroform.

Key words: ammonium hexafluorosilicates, anti-caries agents, identification.

REFERENCES

  1. O’Mullane DM, Baez RJ, Jones S, et al. Fluoride and oral health. Community Dental Health. 2016; 33: 1-31. doi:10.1922/ CDH_3707O’Mullane31
  2. Whelton HP, Spencer AJ. Fluoride revolution and dental caries: Evolution of policies for global use. J Dent Res. 2019; 98 (8): 837-846. https://doi.org/10.1177/0022034519843495
  3. Gelmboldt V.O., Anisimov V.Yu. Ammonium hexafluorosilicates: a new type of anti-caries agents. Pharm journal. 2018; (5-6): 48-69. DOI:10.32352/0367-3057.5-6.18.04 (in Ukrainian)
  4. Gelmboldt VO, Kravtsov VCh, Fonari Ammonium hexafluoridosilicates: Synthesis, structures, properties, applications. J Fluorine Chem. 2019; 221 (5): 91-102. https://doi.org/10.1016/j.jfluchem.2019.04.005
  5. Politz AR, Scott L, Montz H. Ammonium hexafluorosilicate: A prospective alternative to silver diamine fluoride. Undergraduate Research Scholars 2020. https://hdl.handle.net/1969.1/189278
  6. Duffin , Duffin M., Grootveld M. Revisiting fluoride in the twenty-first century: Safety and efficacy considerations. Front Oral Health. 2022; 3: 873157. https://doi.org/10.3389/froh.2022.873157
  7. Gelmboldt VO, Anisimov VYu, Bevz NYu, Georgiyants VА. Development of methods for identification of cetylpyridinium Der Pharma Chemica. 2016; 8 (1): 169-173. http://derpharmachemica.com/archive.html
  8. Gelmboldt VO, Anisimov VYu, Shyshkin IO, Fonari MS, Kravtsov VCh. Synthesis, crystal structures, properties and caries prevention efficiency of 2-, 3-, 4-carboxymethylpyridinium J Fluorine Chem. 2018; 205 (1): 15-21.
  9. Gelmboldt VO, Shyshkin IO, Anisimov VYu, Fonari MS, Kravtsov VCh. Bis(3-hydroxymethylpyridinium) hexafluorosilicate monohydrate as a new potential anticaries agent: Synthesis, crystal structure and pharmacological properties. J Fluorine 2020; 235: 109547. https://doi.org/10.1016/j.jfluchem.2020.109547
  10. Gelmboldt VO, Shyshkin IO, Fonari MS, Kravtsov VCh. Synthesis, crystal structure and some properties of 4-hydroxymethylpyridinium hexafluorosilicate. J Struct Chem. 2019; 60 (7): 1150-1155. https://doi.org/10.1134/ S0022476619070175
  11. Gelmboldt VO, Anisimov VYu, Shyshkin IO. Synthesis of octenidine hexafluorosilicate as new potential caries preventive and antibacterial Pharm rev. 2017; (3): 13-16 (in Ukrainian). https://doi.org/10.11603/23120967.2017.3.7870
  12. State Pharmacopoeia of Ukraine: in 3 vol. / State enterprise “Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicinal Products”. 2nd edition Kharkiv: State enterprise “Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicinal Products”. (in Ukrainian).
  13. Pharmaceutical chemistry: for higher pharmacy students education closing and pharmacy Ph.D. honey. education closing III-IV levels of accreditation / in general ed. P.O. Bezugly. 3rd ed., revised, revised. Vinnytsia: Nova Kniga, 2017. 456 p. (in Ukrainian)
  14. Pharmaceutical Analysis of medicinal products by functional groups: teaching. manual / O.O. Tsurkan, I.V. Nizhenkovska, O.O. Hlushchenko. 3rd ed. K.: VSV “Medicine”, 2019. 152 p. (in Ukrainian)
  15. Urbansky ET. Fate of fluorosilicate drinking water additives. Chem Rev. 2002; 102: 2837-2854. https://doi.org/10.1021/cr020403c
  16. Chebotarev O.M. Acid-base equilibria in silicic hydrofluoric acid solutions and their ionic-molecular composition. ONU Bulletin. Chemistry. 2003. V. 8, No 7. P.46-71.
View article PDF