N 4 (185) 2023. P. 21–26

WHITE RATS’ THYROID GLAND MORPHOLOGICAL STATE AFTER HYPEROSMOLAR SOLUTIONS OF LACTOPROTEIN WITH SORBITOL OR HAES-LX-5% ADMINISTRATION

О. І. Tiron

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2023-4-4

Burn injuries are among the most common and severe diseases in people, second only to traffic injuries. The thyroid gland is one of the first to be affected by high temperature altering effect. When investigating the issue of thyroid gland thermal damage pharmacological correction, we proceed from the classical fundamental concept regarding its pathogenetic validity.

The aim of the work is to study histological and ultrastructural changes in the thyroid gland of rats under hyperosmolar solutions of lactoprotein with sorbitol or HAES-LX-5% administration.

Materials and methods. Intact rats were injected with a colloidal hyperosmolar solution of lactoprotein with sorbitol and HAES-LX-5% into the lower vena cava. On the 1st, 3rd, 7th, 14th, 21st and 30th days of the study of the thyroid gland, both histological preparations and electronograms were studied following the generally accepted method.

Results and discussion. Animals’ thyroid gland microscopic investigations during the entire period of observation after the hyperosmolar solutions of lactoprotein with sorbitol, or HAES-LX-5% seven-day administration, showed the organ structure preservation without signs of pathological changes development. The author considers it methodologically correct and experimentally justified from pathophysiological point of view to conduct further series of studies focused on colloidal hyperosmolar solutions of lactoprotein with sorbitol and HAES-LX-5% testing protective effects under thyroid gland burning.

Кey words: thyroid gland, thermal damage, colloidal hyperosmolar solution of lactoprotein with sorbitol, HAES-LX-5%, pathogenetically justified pharmacocorrection.

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