It was demonstrated that administration of first line antitubercular medicines in male rats caused cytochrome P-450 isoenzymes genes translational activation with simultaneous increase of their mRNA in testes. At the same time spermatogenic epithelium had morphological and morphometric changes. Modulation of cytochrome P-450 isoenzymes genes expression in testes could be one of the reasons of experimental animals’ spermatogenesis and reproductive function disorders.
