N 1–2 (179–180) 2022. P. 59–62

A MODERN LOOK AT THE PROBLEM OF ERYTHEMATOUS FACIAL CONDITIONS IN ROSACEA

M. E. Zapolskyi, M. M. Lebediuk, N. B. Prokofieva, Yu. V. Tepliuk, D. M. Zapolska

Odesa National Medical University, Odesa, Ukraine
Clinic “Renaissance-Medical”, Odesa, Ukraine

DOI 10.54229/2226-2008-2022-1-2-11

The etiological factors of erythema of the face in rosacea are analyzed in the article. The role of vasoactive peptides, inflammatory mediators and ticks of the genus Demodex in the pathogenesis of the disease has been determined. The main methods of treatment of the disease are considered, including phototherapy with narrowband pulsed radiation and platelet autologous plasma (TAP). Current data indicate the acceleration of natural mechanisms of skin regeneration due to the presence of platelet-derived growth factors and modulation of endothelial reparative function, so the introduction of platelet autologous plasma is a promising method of treating patients with this dermatosis.

Key words: rosacea, platelet autologous plasma, facial erythema, platelet growth factors.

REFERENCES

  1. Zouboulis C, Katsambas A, Kligman A. Pathogenesis and Treatment of Acne and Rosacea. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014 (in English).
  2. Grilloa E, Rita Travassos A, Boixedaa P, Cuevas A, Pérez B, Paoli J, Jaéna P. Histochemical Evaluation of the Vessel Wall Destruction and Selectivity After Treatment with Intense Pulsed Light in Capillary Malformations. Actas Dermosifiliogr. 2016; 107(3):215–223. DOI: 10.1016/j.ad.2015.10.006 (in English).
  3. Schoenewolf NL, Barysch MJ, Dummer R. Basics in Dermatological Laser Applications. Curr. Probl. Dermatol. / ed. Bogdan-Allemann I, Goldberg DJ. Basel: KARGER. 2011; 42: 166–172 (in English).
  4. Papageorgiou P et al. Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results. Br J Dermatol. 2008; 159 (3): 628–632. DOI: 10.1111/j.1365-2133.2008.08702.x (in English).
  5. Karsten AE. Effect of Wavelength, Epidermal Thickness and Skin Type on the Required Dose for Photodynamic Therapy. International Conference of the World Association of Laser Therapy. WALT. 2008; 137–43 (in English).
  6. Chen W, Plewig G. Human demodicosis: revisit and a proposed classification. Br J Dermatol 2018; 170: 1219–1225 (in English).
  7. Forton FM, Germaux M-AE, Thibaut SC et al. Demodicosis: descriptive classification and status of Rosacea, in response to prior classification proposed. J Eur Acad Dermatol Venereol. 2019; 29: 829–832 (in English).
  8. Wilkin J, Dahl M, Detmar M et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002; 46: 584–587 (in English).
  9. Tan J, Almeida L, Bewley A et al. Updating the diagnosis, classification and assessment of rosacea: recommendations from the global Rosacea Consensus (ROSCO) panel. Br J Dermatol. 2017; 176: 431–438 (in English).
  10. Chen WC, Plewig G. Are demodex mites principal, conspirator, accomplice, witness or bystander in the cause of rosacea? Am J Clin Dermatol. 2015; 16: 67–72 (in English).
  11. Elston DM. Demodex mites as a cause of human disease. Cutis. 2005; 76: 294–296 (in English).
  12. Bevins ChL, Liu F-T. Rosacea: skin innate immunity gone awry? Nat Med. 2007; 13: 904–906 (in English).
  13. Forton F. Papulopustular rosacea, skin immunity and demodex: pityriasis folliculorum as a missing link. J Eur Acad Dermatol Venereol. 2019; 26: 19–28 (in English).
  14. Nutting WMB, Andrews JRH, Desch CE. Studies in symbiosis: hair follicle mites of mammals and man. J Biol Educ. 1979; 13: 315–321 (in English).
  15. Ayres SJr, Ayres SIII. Demodectic eruptions (Demodicidosis) in the human. Arch Dermatol. 1961; 83: 816–827 (in English).
  16. Shelley WB, Shelley ED, Burmeister V. Unilateral demodectic rosacea. J Am Acad Dermatol. 1989; 20: 915–917 (in English).
  17. Hoekzema R, Hulsebosch HJ, Bos JD. Demodicidosis or rosacea: what did we treat? Br J Dermatol. 1995; 133: 294–299 (in English).
  18. Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2019; 60: 453–462 (in English).
  19. Cribier B. Rosacea under the microscope: characterisctic histological findings. J Eur Acad Derm Venereol. 2018; 27: 1336–1343 (in English).
  20. Forton F, Seys B. Density of Demodex folliculorum in rosacea: a case control study using standardized skin surface biopsy. Br J Dermatol. 1993; 128: 650–659.
  21. Bonnar E, Eustace P, Powell FC. The Demodex mite population in rosacea. J Am Acad Dermatol. 1993; 28: 443–448 (in English).
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