N 1–2 (179–180) 2022. P. 54–58

THE PECULARITIES OF TUBERCULOSIS, CAUSED BY BEIJING STRAINS

М. М. Chesnokova, Yu. І. Bazhora, K. О. Antonenko, K. V. Ostapchuk

Odessa National Medical University, Odesa, Ukraine

DOI 10.54229/2226-2008-2022-1-2-10

East Asian family Beijing M. tuberculosis is a family characterized by active distribution. The article analyzes the association between the features of the course of newly diagnosed tuberculosis in patients infected with pathogens of the Beijing family in comparison with the non-Beijing group. Cultures of M.tuberculosis for molecular genetic research were obtained from 87 patients with first diagnosed pulmonary tuberculosis. According to the presence of the IS6110 insertion fragment in the dnaA-dnaN region, 26,4% of the isolated cultures were reffered to the Beijing family. The medical records of 87 patients with pulmonary tuberculosis were analyzed. Patients infected with pathogens of the Beijing family more often has disseminated form of tuberculosis then infiltrative (60,9% to 30,5%, RR 2,0 CI 1,0 – 4,03), longer period of positive bacterioscopic and cultural tests for M.tuberculosis (RR 1, 8 CI 1,04 – 3,01), more common treatment failure. Higher frequency of mutations of the katG, inhA, rpoB genes, which cause resistance to isoniazid and rifampicin, and multiresistance was detected more often compared to non-Beijing pathogens. In the group of Beijing strains, the level of multiresistance detected by cultural method 31,6% versus 8.5% in non-Beijing, i.e. strains of the Beijing family were characterized by multiresistance 3.7 times more often according to the cultural study than isolates of the non-Beijing group (р<0.05; χ2=8.22) The obtained results permit to speculate that M. tuberculosis infection of the Beijing family is a risk factor for more severe corse of the disease.

Key words: tuberculosis, effectiveness of treatment, Beijing family, drug resistance, M.tuberculosis.

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