N 1–2 (179–180) 2022. P. 9–13

STUDY OF THE INFLUENCE OF (Mg, Co) BIS(CITRATO)GERMANATES ON MORPHOLOGICAL CHANGES OF THE LIVER

M. V. Matyushkina, K. F. Shemonayeva, I. Y. Seyfullina, O. E. Martsynko, N. M. Oliynyk, V. L. Berbek

Odessa National Medical University
Odessa I.I. Mechnikov National University

DOI 10.54229/2226-2008-2022-1-2-1

The search for new and safe drugs has led to a purposeful synthesis of coordination compounds of metals with bioligands based on metals – hermacite (magnesium bis (citrate) germanate), gercocyte (magnesium bis (citrate) germanate). The aim of the study was to investigate the morphological changes in the liver of rats after administration of (Mg, Co) bis (citrate) germanates in subacute and subchronic experiment.

Materials and methods of research. The experiment was performed on mature male Wistar rats weighing 180-250 g, which for 28 days and 3 months intraperitoneally administered (Mg, Co) bis (citrate) germanates at doses of 1/40, 1/110 and 1/135 LD50 and studied morphological changes in the liver.

Research results and their discussion. The course of administration of compounds at doses of 1/40 LD50 for 28 days was accompanied by dyscirculatory changes in the liver, as well as moderately pronounced dystrophic changes in hepatocytes. In general, more pronounced changes in the tissues of rats were observed under the influence of hercocytes (foci of destruction of liver tissue). The course of administration of doses of 1/40 LD50 for 3 months was marked by more pronounced dystrophic changes in the liver. Subchronic course administration of compounds at doses of 1/110 LD50 was accompanied by minor morphological changes. When comparing morphological changes in rat tissues, cobalt-containing compound had a slightly more pronounced effect. It is noteworthy that toxic effects did not accompany the course of administration of BAS with doses of 1/135 LD50 and liver tissue did not differ from the control group.

Key words: (Mg, Co) bis (citrate) germanates, subacute toxicity, morphological changes.

 

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