The peculiarities of the chronorhythmologic changes of the renal functions have been studied in an experiment in case of blocking renal prostaglandin (PG) synthesis in rats with the normal pineal function and against a background of pineal hyperfunction. It has been established that the renal PG are an important factor of regulating chronorhythms of the chief renal functions. Indometacin blockade of the renal PG synthesis against a backgraund of pineal hyperfunction inhibits the rate of glomerular filtration, increases the level of the protein excretion and its urinary concentration, as well as elevates natriuresis and impairs the processes of acid regulation.
