The article concernes the participation of glucocorticoid mechanisms in pathogenesis of depression. An abundance of glucocorticoids inhibits neurogenesis, which is one of supporting mechanisms of neuronal ensembles morpho-functional integrity. The antidepressants restore an activity of multi-level system of glucocorticoids secretion regulation, diminish their damage action on neuronal ensembles, enhance neurotrophins expression and promote neurons vital activity.
