There was investigated the role of fibronectin, IV type collagen and endothelin-1 in the development of placenta insufficiency in spontaneous and induced multiple pregnancy. It was established that intensification of fibronectin and the IV type collagen expression signify high-level of sclerotic processes in placenta of different genesis multiple pregnancy. The depression of endothelin-1 expression may cause the deterioration of compensatory-adaptive processes in a system of mother–placenta–fetus.
