It was studied variants of immunophysiological response in patients with polytrauma. Differently directed immune responses depending on degree of trauma and shock severity were diagnosed. In 10% of patients there developes associative immunopathological responses featured by increase of anti-inflammatory IL-4, Ig E and decrease of CD 4 level of T-helpers. A considerable decrease of IL-2 is unfavourable prognosticating factor for the patients with traumatical disease complicated by sepsis and is an indication for application of cytokines for such category of patients. A considerable increase of the given index requires immunosupsressive drugs application.
