For the women with preeclampsia of 1st degree the neuroendocrinal regulation of homeostasis is broken in 1st trimester of pregnancy with creation of primary placental insufficiency, oppression of stress-realizing function of the hypothalamopituitary system, development of insulin resistance, that as a whole testifies to dysadaptation of the woman organism to pregnancy. In 1st trimester the state of the fetoplacental complex in pregnant women with preeclampsia, irrespective of a degree of gravity, is characterized by hormones production dysbalance, which is the evidence of primary placental insufficiency development.
