The researches carried out resulted in the fact that a long-term g-irradiation in a total doze of 1.0 Gr caused stable changes of acetilation activity of hyston and non-hyston chromatin of spleen cells nuclei. Expressiveness and direction of the changes revealed depended on time after irradiation and type of peptide. The greatest changes took place in relations, forming the core of nucleous cerebrum and labily connected with DNA non-histon peptides. On the basis of the results obtained we suppose that these disorders may cause the density of peptide molecular charge decrease, weakening of interlinking “DNA-peptide” and damage of genome expression initial stages.
