The effects of the new coordinating Germanium dyphosphonate compounds with nicotinic acid (MIGU-4), nicotinamide (MIGU-5) and Mg2+ (MIGU-6) on oxotremorine-induced tremor, salivation and reserpine-induced rigidity were examined in mice and rats. The wide-spread preparations L-DOPA, flupertin, ipratropium and glicopirrollate were used as comparison drugs. Carried out investigations revealed the neurotropic activity of the new biological active substances, which dose-dependently decrease the both tremor and muscle rigidity. The conclusion about central dose-dependent anticholinergic action of these compounds was made.
