Interleukin-6 (IL-6) is known to be involved in the pathogenesis of a wide variety of diseases, including endometriosis and ovarian cancer. We used pyrosequencing technique to investigate a common G/C polymorphism at position -174 of the IL-6 gene promoter in patients with endometrial cancer. The distribution of genotype frequencies was not statistically different between the study group and the control group among women heterozygous for the protective C-allele (-174G/C) — 54,5 % versus 61.5 %, respectively, and among women homozygous for the C-allele (-174C/C) — 6,1 % versus 7.7 %. This polymorphism does not contribute significantly to overall disease susceptibility.
