At the experiment on 60 rats at the age of 2.5–3 months the influence of sublingual gels, containing probiotic inulin, antioxidant-lipoic acid, boiflavonoids of sophora Japanese or their combinations, on the biochemical indices of blood serum after reproduction of diabetes mellitus by single intraperitoneal introduction of alloxan, dosed 100 mg/kg, was studied. During four weeks, 50 g of gel were applied daily to the oral mucosa of rats with diabetes. It was determined that the gel with sophora tincture reduces considerably hyperglycemia, LPO, activates AOS and increases the level of tripsin inhibitor. The above-mentioned gels had no influence on general proteolytic activity.
