General proteolytic activity (GPA), activity of catepsin D and inhibitory level of tripsin were examined in blood serum of 55 patients with latent syphilis (LS ) and 12 healthy persons.
It was determined siqnificant increase of all indices in GPA. The treatment with penicillin and vitamins B6 and B12 (20 patients) for 28 days showed decrease of activity by 28–30% of protease and increase by 40 % of inhibitory level.
Additional treatment with bifidumbacterin and inulin (35 persons) showed decrease of proteolytic activity by 56–62% and two-fold increase of inhibitor level.
It may be assumed that disbacteriosis plays an important role in pathoqenesis of LS.