In this article there are experimental research data of antiarrhythmic activity of germanium derivatives with various ligands — MIGU-4 (with nicotinic acid), MIGU-5 (with nicotinamid), MIGU-6 (with succinic acid) on an isolated papilar strip of the myocardium of guinea pig. It was found, that MIGU-6 is the most active according to the influence on alteration of maximal reproduced contraction rate of cardiac papilar muscle (in concentration 10-6, 10-5 and 10-4 M/l). It has been established, that MIGU-6 in dose-dependent manner prolongs the phase of repolarization. The most stable changes of value of duration τ2 have been revealed at concentration MIGU-6 equal 10-6 M/l.
