Under conditions of the acute experiment on rats in which mechanical brain trauma was modeled, the dynamics of focal epileptogenesis was investigated, which was induced in left ventral hippocampus via microinjection of sodium salt of benzilpenicillin, NMDA, kainic acid and strychnin nitrate. It was established that seizure susceptibility to epileptogenic effects of NMDA and kainic acid was raised. The decreasing of susceptibility to NMDA effects was registered after pentoxyphyllin administration, which reduced elaboration of endogenous proinflammatory cytokines.
