The data of the experimental investigations are given on the study of comparative mesna and L-carnitine neuroprotective efficacy under conditions of experimental neurotoxicity induced by taxol, vincrisrine and cysplatine in rats. The neurotoxicity signs were estimated by rats’ body weight measuring, “open field” motor activity indices and muscle tone evaluation as well as tail nerve conductance velocity determination. Mesna and L-carnitine administration resulted in neurotoxicity indices avoidance which were expressed in rats by the weight and motor activity indices increasing as well as muscle tone increasing and nerve conductance velocity indices increasing.
