The analysis of various genetic abnormalities in patients suffering from endometrial carcinoma was carried out in the article. It was shown that mutation in genes K-ras, PTEN, β-kathenin and microsatellite instability are registered most often when the estrogen-depending endometrial carcinoma developing, while the aneuploidism and mutations in genes р53, р16, Е-kadgerin, her2/neu are more typical for the estrogen-independent endometrial carcinoma. Knowledge of genetic changes when the endometrial carcinoma developing are necessary when forming the given pathology risk groups among the females.
