TISSUE RESPIRATION AND OXIDATIVE PHOSPHORYLATION IN MITOCHONDRIAS OF HEART AT EXPERIMENTAL MYOCARDIAL DYSTROPHY AND ITS MEDICINAL CORRECTION

The tissue respiration and oxidative phosphorylation in mitochondrias of the cardiac muscle in different terms of development of experimental myocardial dystrophy and at spontaneous renewal of the studied indices were studied at present work. Prophylactic and medical efficiency of new BAS — magnesium-oxyethylyndiphosphonategermanate was shown for the first time (MIGU-6). Prophylactic introduction prevented development of myocardial dystrophy, while a medical one — more than 2 times, as compared to a spontaneous renewal; decreased the terms of normalization of the tissue respiration and oxidative phosphorylation and their coupling.