ANALYSIS OF BIPHOSPHONATOGERMANATES NEW DERIVATIVES PHARMACOKINETICS, BASED UPON THE EVALUATION OF THE STATISTICAL MOMENTS OF THEIR DISTRIBUTION IN THE ANIMAL ORGANISM

The article presents a new pharmacokinetic method, which is based upon the evaluation of the statistical moments and allows to describe the influence of all the kinetic parts on the total scheme of the distribution of the biologically active substance introduced into the organism. The elaborated method helps to establish the features of pharmacokinetics of the biphosphonatogermanates three new derivatives (MIGU-4, 5 and 6). It is determined, that despite of the different chemical structure of these compounds, the complicacy of their kinetic scheme of the distribution in the rats organism is practically identical, which is evidence of the common laws of their masstransfer in the biosystem.