For the first time the antimicrobial properties of 25 synthesized chloro-, bromo- and iodosubstituted distal (“symmetric”) and proximal (“non-symmetric”) benzo- and dibenzocrown ethers and their non-cyclic relative compounds were compared. It was discovered, that many of the researched macrocycles suppress the growth of grampositive microorganisms, while the absence of activity on gramnegative structures is demonstrated by all discussed compounds. It was established, that the transformation of inactive benzocrown ethers into the corresponding mono- or diagonal derivative leads to the appearance of high or intermediate activity.
