Experiments were conducted on 30 white non linear male rats with the weight 80–90 g. They were introducted gentamycin in a doze of 10 mg/100 g of the body weight once a day for 7 days under conditions of water diuresis. The experiment showed nephrotoxic effect of the preparation which manifested itself in dysfunction of nephron proximal tubuls and considerable change of renal osmoregulatory function, decrease of ability for osmotic urine dilute. Introduction of an amber acid, as a power substrate, and preductal as stabilizer of synthesis power substrate, at gentamycin nephropathy, testify to positive influence of the preparations on osmoregulatory function of kidneys.
