The article presents the results of the study of the effect of combination therapy on the state of AOC and POL systems, in particular, the feasibility of using flavicin, diosmin and quercetin in combination with L-arginine for the treatment of microangiopathies on the background of type 2 diabetes.
It was found that flavonoid compounds showed a pronounced antioxidant effect in models of chronic complications of type 2 diabetes (diabetic retinopathy and diabetic nephropathy) when used in combination with L-arginine. The most pronounced effect was observed in the group of animals treated with quercetin and L-arginine, the least pronounced — in the group of animals treated with quercetin and L-arginine. The obtained data allow to recommend a combination therapy of quercetin and L-arginine to reduce the risk of late complications of type 2 diabetes due to the pronounced antioxidant properties.