Chronic prostatitis is a common pathology for men. In the structure of chronic prostatitis, more than 90% of cases occur in chronic non-bacterial prostatitis and chronic pelvic pain syndrome, the etiology, the pathogenesis of which has not been sufficiently studied today. Experimental models of cryotraumatic prostatitis have been proposed for the purpose of developing and evaluating the effect of preparations for treating the prostate (protectors of prostate). Non-bacterial cryotraumatic prostatitis was caused by local irrigation of a previously surgically exposed front surface of the central part of the prostate gland (isthmus and ventral parts) within 5 seconds with the Wartner warts remover, after which the wound surface was sutured. The starting point of cryotrauma is angiospasm followed by ischemia of the prostate tissue, alteration of glandular epithelium and stroma cells, which are primary in the development of the inflammatory process in the prostate gland; cryotraumatic prostatitis application the Wartner (Netherlands) reproduces the pathogenesis of nonbacterial prostatitis. Chondroitin sulfate, Tribestan, combined applying of Chondroitin sulfate and Tribestan, Bioglobin-U, which have apparent anti-inflammatory properties. The effect of Chondroitin sulfate, Tribestan, combined applying of Chondroitin sulfate and Tribestan, Bioglobin-U to reduce the concentration of C-reactive protein exceeded the effect of Prostaplant Forte as a comparison preparation.
