Relevance. Today, COPD is regarded as a systemic disease that is often associated with hypertension, coronary heart disease, osteoporosis, metabolic syndrome, and diabetes. In view of the significant mutual effect of the above diseases, the study of the features of lipid metabolism disorders in COPD of professional etiology is of great importance.
Purpose of the study. To determine the features of the serum lipid spectrum in COPD of a professional etiology of varying degrees of severity.
Material and methods of investigation. 186 results of laboratory studies of patients with COPD of mining workers were analyzed. The clinical group consisted of patients with different stages of COPD, namely: COPD I — 45 patients, COPD II — 51 patients, COPD III — 48 patients. The control group consisted of 42 employees of the mining industry without respiratory pathology. The serum lipid spectrum was assessed by total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein-A1 and apolipoprotein-B.
Results of the study. Analysis of the lipid profile of patients with COPD of professional etiology of varying severity showed a general trend in quantitative changes in the lipid profile. An increase in the levels of total cholesterol 1.5–1.6 times, triglycerides 1.2–1.5 times, low-density lipoprotein cholesterol 2.2–2.6 times, very low-density lipoprotein cholesterol 1.2–1.5 times, atherogenic coefficient 2.0–2.7 times, lipoprotein-A1 1.2–2.1 times, apolipoprotein-B 1.1–1.2 times and the ratio Apo-B/Apo-A1 1.1–1.7 times, together with the severity of the disease, while there was a decrease in high-density cholesterol levels of 1.1–1.2 times and apolipoprotein-A1 by 1.1–1.4 times.
Conclusions. The data obtained indicate a violation of the lipid composition in the serum of patients with COPD of professional etiology. This may indicate the interrelation of the influence of the chronic inflammatory process and disorders in lipid metabolism on the course of the disease.