The article presents the data of studying the activity of some leukocyte intoxication indices in workers of mining and metallurgical industry with pneumoconiosis associated with COPD. High levels of bacillonuclear leukocytes, eosinophils, erythrocyte sedimentation rate (ESR) in peripheral blood have been revealed. The levels of most intoxication indices in patients with pneumoconiosis associated with COPD were higher than those in patients with other occupational lung diseases: the leukocyte intoxication index ranged from 14.2 to 60.0%, the systemic inflammation index ranged from 17 to 45.6%, the general intoxication index was from 9.8 to 36.1%. The performed studying has been revealed that the intoxication processes cause the increase of chronic inflammation activity, immune reactivity disorders, development of autoimmune processes in this category of patients, resulting in the progression of the disease with unfavorable prognosis.
