The relevance of a problem of Sjögren’s syndrome is caused by rather considerable prevalence, diversity and mosaicity of a clinical picture that can be the cause of overdue diagnosis. Existence of significant amount of various organ-nonespecific and organ-specific autoantibodies, in particular to tissues of endocrine glands, causes complexity of pathogenetic mechanisms and lesion of organs at Sjögren’s syndrome. Studying condition of adrenal glands in the dynamics of a Sjögren’s syndrome and establishment of a possibility of correction of disturbances in an experiment a natural immunomodulator — amaranth oil was the purpose of work. The work was formed as experimental clinical trial.
Experimental and clinical research of a role of hormonal regulation in a pathogenesis of Sjögren’s syndrome was conducted. Results of experimental studies showed that a long course of Sjögren’s syndrome model was followed by structurally functional manifestations of exhaustion and dystrophy in adrenal cortex at experimental animals. Clinical observations showed that in initial stages of Sjögren’s syndrome cortisol level in blood raised, and at the long course of pathology decreased. Authors suppose that it is connected with exhaustion and dystrophy of adrenal cortex. Change of activity of adrenal cortex can be one of mechanisms in a pathogenesis of Sjoren’s syndrome. Administration of the amaranth oil to an experimental animal with model of a Sjögren’s syndrome a dose 0.2 ml daily kept structurall and functional characteristics of adrenal glands and reduced destructive changes in a parotid glands. Authors suppose that an amaranth oil protects damages of adrenal glands at this pathology and can be used in this treatment.
