The protein composition of the blood plasma is a complex dynamic system that reverses physiological and pathophysiological processes in the human body.
Objective. To assess the direction of homeostatic shifts of the dynamic light scattering (DLS) spectra of blood plasma in children with community-acquired pneumonia (CAP).
Materials and methods. The DLS spectra of blood plasma in 64 children with CAP were analyzed. Children were divided into age groups: 1 — from 1 to 6 years (21 children), 2 — from 7 to 13 years (22 children), 3 — from 14 to 18 years (21 children).
Results. Determination of the general orientation of the DLS spectra of blood plasma in children with CAP has established the hydrolytic orientation predominance of the shifts in children of 1 group (65.56±10.54)% and 3 group — (76.17±9.52)% (p<0.05). In children of the 2nd age group, are present all types of homeostatic shift directions in equal amounts. An association between the important clinical signs of CAP and the shift characteristics of the DLS spectra of blood plasma was established. The hydrolytic orientated homeostatic shift of the DLS spectra of the blood plasma is significantly more often detected in patients with segmental CAP (66.00±6.69)%, with local complications of CAP (90.00±9.48)%, long-lasting fever in children on the background of standard hospital therapy of CAP (58.88±6.89)% (p<0.05).
Conclusions. The DLS spectra of children’s blood plasma are characterized in a shift towards particles with a small hydrodynamic radius. The hydrolytic orientation of the DLS spectra is more reliably detected in patients with signs of an negative course of CAP.