Liver cirrhosis is accompanied by hepatic and hematologic complications, for example, thrombocytopathy. The possibilities of therapeutic influence on liver cirrhosis are limited, the prognosis can be improved at the initial stages of the disease due to the influence on the etiologic factor. Previously, we demonstrated a positive effect of intrahepatic injection of platelet-rich plasma. Taking into account the potential limiting effect of thrombocytopathy on the effecacy of this technique, we conducted an electron microscopic study of the platelets morphology in rats with toxic-induced liver cirrhosis. Increase in the number of activated platelets with marked degranulation due to decreasing the density of alpha- and delta-granules has been revealed.
