Hyperproliferative processes of endometrium (HPE) in modern gynecology are considered as a polyethiological disease, which is influenced by various endogenous and epigenetic factors for development, progression and transformation. Endometrial hyperplasia, in combination with concomitant gynecological and extragenital pathology, increases the risk of developing uterine cancer in these patients.
Aim. To determine and evaluate the most important risk factors for the development of complex atypical endometrial hyperplasia in women of reproductive and perimenopausal age.
Materials and methods. A retrospective analysis of anamnestic data was performed in 42 patients with a pathologically confirmed diagnosis of complex atypical endometrial hyperplasia at the age of 29–67 years and in 30 women in the control group without verified HPE.
Research results. The most significant risk factor for complex atypical endometrial hyperplasia development is age > 50 years (OR=119.89; 95% CI 6.83–2104.31); Heredity — OR=80.78 (95% CI 4.63–1409.13). For patients with early menarche and late menopause, OR is 31.9 (95% CI 3.97–256.22) and 66.95 (95% CI 3.84–1166.55) respectively. Relatively high risk of complex atypical endometrial hyperplasia is associated with thyroid diseases — OR=27.91 (95% CI 1.58–491.23), obesity OR=18.66 (95% CI 3.925–88.77), arterial hypertension OR=14.00 (95% CI 2.95–66.41).
Conclusions. In order to timely increase the prevention, early diagnosis of HPE, it is necessary to identify their risk factors at the prehospital stage and to correct them.