The study of the combined use of the preparation of polyhydric alcohols in conjunction with L-arginine is practically important, relevant and unexplored.
The purpose of the work was to investigate the effect of combined use of sorbilact and L-arginine on the state of the cardiovascular system in endogenous intoxication syndrome (EIS).
Methods. State of the cardiovascular system have been studied in patients of the following groups. The I group consisted of 31 patients with systemic inflammatory response syndrome. The II group consisted of 22 patients with EIS who were treated according to Surviving Sepsis Campaign 2016 (standard therapy). The III group consisited of 24 patients with EIS, who received sorbilact in addition to standard therapy. The IV group included 21 patients with SEI who received standard therapy as well as Sorbilact and L-arginine. Sorbilact infusion and solution of L-arginine was performed intravenous drip according to the instructions.
Results. L-arginine causes a decrease in mean blood pressure (by 6%, p<0.05) due to the diastolic component (by 7%, p<0.05) compared with patients where only sorbilact was used. Infusion of L-arginine initiates a decrease in the systemic vascular resistance (by 14%, p<0.05) and an increase in stroke volume and cardiac output (8%, p<0.05) and the heart pumping capacity index (by 22%, p<0,05) in relation to the indices obtained after infusion of sorbilact.