This paper shows that the modeling process of bronchial asthma with chronic periodontitis is accompanied by an increase, in comparison with the control group, of endogenous intoxication indicators: average mass molecules and the erythrocytic index of intoxication in endogenous intoxication in guinea pig males on the 4th, 18th, 25th day of experiment. The corrective effect of thiotriazolin on endogenous intoxication indicators.
The aim of the study. Determination of some indices of endogenous intoxication in blood of guinea pigs in the modeling process of experimental bronchial asthma with chronic periodontitis and their correction with thiotriazolin.
Materials and methods. Experiments were conducted on 50 guinea pigs (males), with body weight 0.25–0.27 kg. Animals were divided into five groups of ten animals in each. Intact guinea pigs were the first group. Animals with experimental bronchial asthma with chronic periodontitis before correction — the second, third, fourth group respectively on the 4th, 18th, 25th day of the experiment. Animals with experimental bronchial asthma with chronic periodontitis after correction with thiotriazolin on 25th day of the experiment were the fifth group. Experimental bronchial asthma was reproduced by V. I. Babich method. Chronic periodontitis was reproduced by O. N. Voskresens’kyy method. In blood of intact guinea pigs and animals with experimental bronchial asthma with chronic periodontitis was determined the content of average mass molecules at a wave length of 254 nm by the method of I. A. Volchegorsky and co-authors, erythrocytic index of intoxication was determined by the method of A. A. Togobayev and co-authors. Statistical methods of processing the results of the study were done by the method of variation statistics using Student’s criterion.
Results and discussions. The results of the studies showed that endogenous intoxication markers increased unidirectionally, depending on the periods of asthma formation. Therefore, in guinea pigs, the levels of average mass molecules and erythrocytic index of intoxication was increased in all the days of the experiment. The use of thiotriazoline during 7 days from 18th to 25th day reduced these indices, which indicates a corrective effect of the drug on endogenous intoxication 25th day of the experiment.
Conclusions. The obtained results indicate significant changes in the endogenous intoxication indices in blood of experimental animals with bronchial asthma with chronic periodontitis and corrective effect of thiotriazoline.