Objectve: to evaluate the effectiveness of the proposed naturopathic method as an alternative way of pregravid preparation in women with adenomyosis.
Patents and methods: 70 patients of reproductive age (29–32 years) with adenomyosis in 1–2 stage. Control group — 38 healthy women. Differences between the groups: pregravid preparation (group 1 received dietary recommendations and metered physical exercises, group 2 — combined oral contraceptives). Levels of progesterone, placental lactogen, tumor necrosis factor, interleukin-6, percentage of pregnancy, early miscarriage risks and reproductive loss were studied.
Results: in 87% of women with adenomyosis there were manifestations of inflammation of different localization in pelvis, infertility — in 94% of women. The level of IL-6 in women with adenomyosis before treatment was increased more than twice. The increase in tumor necrosis factor-a is associated with dysfunction of the inner organs, as possible development factor of septic complications. The reduction of progesterone in patients with adenomyosis confirms the pathogenetic mechanism of the disease. In group I 30 (81%) had pregnancy, 13 (46.7%) had risk of miscarriage, 4 (13.3%) cases of reproductive loss. Pregnancy in group II was detected in 26 (78.8%) cases, of which 13 (50%) had a risk of miscarriage and 6 (23%) reproductive losses.
Conclusions: pregravid preparation which includes physical activity and dietary nutrition, contributed to improve reproductive function in women with adenomiosis and can be used as an alternative or auxiliary preparation for pregnancy in women with adenomyosis.