Aim. To determine prophylactic action of oral mucoso-adhesive phytogel “Duboviy” at experimental periodontitis into rats.
Materials and Methods. The experimental periodontitis was made in rats by the introduction of hyaluronidase solution intragum. The markers of inflammation (elastase and MDA), degree of infection (urease), the state of non-specific immunity (lysozyme) were determined into gum. The activities of alkaline and acid phosphatases and activity of elastase were determined in dental pulp. The elastase activity was determined into serum.
Results. The hyaluronidase introduction made inflammation into gum, pulp and serum. The hyaluronidase introduction decreased lysozyme activity and increased the degree of dysbiosis into gum and decreased of the mineralisation index of pulp. Phytogel “Duboviy”, which content phenolic substance from oak decreased the degree of dysbiosis, inflammation and raised the mineralisation index.
Conclusions. The phytogel “Duboviy” has parodontoprotective action.