Among the acute infectious diseases, rhinitis occupies a special position. Improper treatment can cause complications. Therefore, the treatment of rhinitis in the initial stages is the optimal for the prevention of severe infectious intracranial diseases. There was created a gel “Imbirol” of local application for the treatment of rhinitis containing a complex of essential oils. The aim was the pathophysiological study of rhinitis and the degree of pharmacological correction with the experimental gel “Imbirol”. The research was conducted on the model of acute inflammation of the nasal cavity caused by caustic soda (chemical rhinitis) and intranasal introduction of Staphylococcus aureus (bacterial rhinitis). During 9 days rats were treated with an experimental gel and a drug called “Pinosol”. The experiment took 36 rats, with bacterial and chemical rhinitis, with treatment and without it. Indicators of peroxidation of lipids and antioxidant system were determined in serum: thiobarbituric acid (TBA) and diene conjugates (DC), reduced glutathione (RG) and catalase (Cat). The obtained research results confirmed the formation of oxidative stress in experimental groups, both in chemical and bacterial rhinitis, according to DK and TBA data at 168.3%, 216.1% (chemical) and 159.4%, 216.1% (at bacterial) compared to intact animals. Application of the experimental new gel “Imbirol” and “Pinosol” allowed to significantly improve the course of both chemical and bacterial rhinitis, that characterized by dynamic equilibrium the indexes of LPO and AOS to a level of intact animals. In group with gel “Imbirol” Cat and RG activity are increased to the level of intact animals: 102.4% and 108.2% (differences between the groups are statistically insignificant). Application of the experimental gel “Imbirol” and “Pinosol” is resulted in the expressed therapeutic effect. The obtained results allow to continue the study of experimental rhinitis, pharmacological influence of the experimental gel “Imbirol”.
