There are presented the results of MIGU-5 interaction with traditional AEP (phenitoin, karbamazepin, valproic acid) and new (lamotridgin, gabapentin, topiramat) by an izobolografic method on the model of 6-Hz induced seizures model in mice. Main feature of the antiepileptic action of MIGU-5, in the conditions of the 6-Hz induced seizures model there was, that achieving of an antiseizure action was possible only at introduction of large doses of MIGU-5, which showed the different types of interaction (summation, sinergism or antagonism) with explored AEP.
