Introduction. Herpetic infection takes a special place among the pathologies of the mucous membrane of the oral cavity and is accompanied by the absence or suppression of all immunity factors and tends to grow. Its aggravation is a contraindication for dental implantation as a factor in the probability of exacerbation of somatic diseases, development of postoperative complications, which requires prevention or treatment before dental implantation.
The purpose of the research was to determine the state of local immunity in patients who are carriers of herpesvirus infection at planning dental implantation.
Objects and methods. 70 patients had been examined oral fluid and peripheral blood before treatment. The level of CD4-lymphocytes and CD3-lymphocytes of CD8-lymphocytes, natural killers — CD16+ — and CD56+ cells was determined. As the comparison group there were used the same indicators of 32 healthy individuals (control).
Results and its discussion. In the blood, leukopenia, lympho-monocytosis of different degree of severity were defined. In the oral fluid, the decrease in the markers of natural killers — CD16+ — and CD56+ cells, CD4+ and CD3 lymphocyte level, in per cent, and in absolute value, the level of CD8 lymphocytes was 1.3 times higher in relative and 1. 4 times in the absolute sense, which led to a decrease of the immunoregulatory index (CD4 / CD8) and indicated an inadequate activity of the immune response.
Conclusion. A violation of the subpopulation composition of lymphocytes and immune deficiency in patients with chronic herpetic infection was found, which probably contributed to the oral mucosa cells membranes integrity disruption and determined the need for immunocorrecting therapy on the eve of dental implantation.