Introduction. The only way of radical treatment of pancreatobiliar cancer is surgical, but the operability of these patients, according to the data of national and world literature is not exceed 20–30 %. Mortality in performing radical surgery in high mechanical jaundice reaches 17–23 %, while the development of acute hepatic failure — up to 45–65 %.
Materials and methods. The results of endoscopic treatment of 735 patients with tumors of the periampullar zone were studied in the clinic of the Institute from 2005 to 2017.
Results. Suprapapillary choledochoduodenoscopy was performed in 105 (14.3 %) patients, plastic and nitinol endobiliary prosthetics in 630 (85.7 %) patients. Complications after endoscopic interventions arose in 81 (11 %) patients.
For patients with potentially resectable tumors, surgical resection is the main treatment, but most patients are treated with high mechanical jaundice symptoms, signs of cholangitis and liver failure, which requires a two-stage treatment, the first step is to decompress extrahepatic biliary tract. Transpapillary decompression of the biliary tract tumors in patients with periampular zones and high anesthesiology operational risk is effective and preferred method of restoring the main bile production preoperatively.