Objective. Definition of the clinical significance of telomerase activity in ordinary cells and various types of hyperplastic endometrium.
Materials and methods. For the study of samples in 30 women aged 38 to 53 years old with histopathological diagnosis of endometrial hyperplasia was conducted: 1st group — simple endometrial hyperplasia without atypia (SG) — 7 samples of the endometrium; 2nd group — complex hyperplasia without atypia (CH) — 8 samples; 3rd group — simple hyperplasia with atypia (SGA) — 8 samples; 4th group — complex hyperplasia with atypia (CGA) — 7 samples. Control study was for 5th group — proliferation phase (PP) — 6 samples; 6th group — phase secretion (SP) — 5 samples.
Results and discussion. Some tendency to increase telomerase activity in proliferative endometrium and inhibition type in secretory phase were determined. Analyzing the data of enzyme activity in the cells of hyperplastic endometrium, the reactivation of telomerase at the complex atypical hyperplasia and slightly reduced rate at Integrated hyperplasia without atypia were discovered. In groups of simple hyperplasia and atypical hyperplasia simple changes in telomerase activity were found.
Conclusions. The statistical analysis of the performed molecular genetic studies alow to consider the telomerase activity as a highly promising diagnostic criteria of endometrial proliferative processes and recommend its feasibility determination for differential diagnosis of benign and malignant proliferative processes which may be taken into account in the determination of the further treatment mode.