The external factors and internal system mechanisms are in the basis of etiology of pathological processes of the oral cavity which manifest as different diseases. The special place among them is taken by the herpetic infection, from 20 the 60% of population of planet are sffering from it and there is a tendency to growth in the developed countries.
The aim of our researches was an estimation of dynamics of biochemical and immunological markers of oral fluid in patients with chronic herpetic stomatitis which need the dental implantation.
Materials and methods. Under our supervision there were 105 patients: control practically healthy (n=35) and two groups of patients with partial secondary adentia, carriers of HI N 1 (n=35) and N 2 (n=35), which need in intracostal dental implantation.
As a result of researches we detected changes of activity of enzymes of mouth liquid and activation of the lipid peroxidation system. In both groups of patients there was a decline of lysozim activity up to 50.7%, which characterized by the decline of the protective function of oral fluid in relation to pathogenic bacteria, that was accompanied by activating lipid peroxidation system.
Results. There were detected changes of biochemical markers of oral fluid in patients suffering from chronic herpetic stomatitis, which need dental implantation, testify to the presence of inflammatory process, destabilizations of the lipid peroxidation system and violation of local immune response, which requires a proper specific medicinal correction.