The influence of hyperhomocysteinemia (HHC) on development and course of preeclampsia are analysed. At the end of the course 167 women with preeclampsia in anamnesis at previous pregnancies (98 retrospective and 69 prospective) on the mutation of enzyme of methylenetetrahydrofolat reductase (MTHFR) — a genetic form of HHC were inspected. In a retrospective group the MTHFR was discovered. Mutation was in 44 (44,8 %) women, in 34 (77,3 %) of them HHC was exposed. In a prospective group from 69 women in 28 (40,6 %) the promoted concentration of homocysteine and high levels of the molecular markers of trombophilia — TAT, F1+2, D-dimer were determined. Conducting of pathogenetic therapy by HHC and thrombophilic folic acid, by the vitamins of group B and clexane from the fertile cycle and first trimester of pregnancy allowed to prevent development of thromboembolism complications and preeclampsia.
