There was studied pharmacokinetics of complexes of germanium with nicotine acid and germanium oxyethylidenediphosphonate with the nicotinic acid and comparative analysis was conducted.
Materials and methods of examination. After compounds intra-abdominal introduction to the “Vistar” line rat-males weighing 140–150 g (at 37.5 mg of germanium per kg of mass) in 0.25; 0. 5; 1; 2; 4; 8; 24 hours the animals were decapitated under the barbituric anesthesia and there were sampled blood, blood plasma, cerebrum, liver, spleen, lungs. Contents of complexes was determined with germanium by the extraction-photometric method.
Results and their discussion. The pharmacokinetics of compounds differed. In case of determination of kinetic parameters there were established regularities which have not been reveled before.
In spite of the fact that common components (nicotine acid and germanium) are present in the chemical structure of the studied BAS, their pharmacokinetic parameters differed. Concentration of germanium in tissues and rate of delivery was higher after MIGU-4 introduction. The rate of processes of elimination depended on the type of tissue. Both BAS had high tissue availability. The results open a prospect fot further study of pharmacodynamics, development of principles of pharmacotherapy for introduction to the medical practice.