Heterogeneous chemicals that exhibit negative impact on humans and animals are considered as “xenobiotics”. Xenobiotics which are characterized by large range of synthesis and wide spread use are oligoesters of polyhydric alcohols under technical name “laprols”. According to the physical and chemical properties and by the structure of molecules they belong to surfactants. Activity of xenobiotics neutralization processes have been studied not enough, so it is necessary to disclose the mechanisms of biological action.
The work uses samples OEF-LP 502 (polioxypropilenglycol) and 503 (polioxypropilentriol) with regulated physical-chemical characteristics. Experiments have been conducted on mature rats of Wistar weighing 180–220 g. There were 10 animals in each group.
Assessment of microviscosity rat’s liver’s microsomal membranes was carried out by lateral diffusion hydrophobic fluorescent probe pyrene. About infractions of rat’s liver microsomes’ membrans’ physicochemical properties have showed their results on the PL’s conditions of action OEF-LP-502 in operating 1/100 LD50 dose in the dynamics of observation. On the 45th day of action OEF-LP 502 and 503 at doses of 1/10 and 1/100 LD50 there were serious infractions of the physico-chemical properties of rat’s liver microsomes’ membranes. Identified changes in physical and chemical properties of rat’s hepatocytes microsomal membranes are the cause of destabilization from exposure to substances with distinct surface-active properties and also due to intensification of lipid peroxidation.