ROLE OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION FOR PATHOGENESIS OF EXPERIMENTAL ASTHMA DEVELOPMENT IN COMBINATION WITH ADRENALINE MYOCARDIAL DAMAGE

The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the lungs of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Researches were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development of EA with AMD there increased lipid peroxidation products level (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the lungs, followed by reduction in their on the 18th and 25th day.